A team from Brazil determined the long-term survival of cirrhotic patients with spontaneous bacterial peritonitis (SBP) treated with ceftriaxone. They also identified predictive factors related to survival.
Some 47 first episodes of SBP treated with ceftriaxone were studied, with a mean follow-up of 272 days.
A total of 19 variables were recorded to evaluate their relation to survival.
The most frequent organism that caused SBP was found to be Escherichia coli (40%).
|Survival after SBP:|
1 month: 68%
6 months: 31%
Spontaneous bacterial peritonitis resolution was achieved in 67% of patients. After resolution, SBP recurrence was observed in 44% of patients.
The cumulative probability of survival was 68% at 1 month and 31% at 6 months.
The researchers found that after univariate and multivariate analyses of all cases, SBP resolution and international normalized ratio (INR) were related to survival.
Another analysis performed, after SBP resolution and SBP recurrence, showed that ascitic fluid-positive culture and INR were predictive of long-term survival.
Dr Alex Vianey Callado França, of the University of Campinas, Brazil, concluded on behalf of fellow authors, "Survival of cirrhotic patients is very short after the first episode of SBP. This fact is probably related to advanced liver disease, as liver dysfunction (INR) is the most important factor related to long-term patient survival."