Hypercoaguable states may play an important role in the pathogenesis of colon ischemia.
To test this hypothesis, members of the Department of Gastroenterology, University Hospital, Heraklion, and the Regional Blood Bank Center, Venizelion Hospital, Heraklion, Greece, have conducted research into the role of acquired and hereditary thrombotic risk factors in patients with a definite diagnosis of colon ischemia.
The research team compared the frequency of several variables involved in the clotting process. These included antiphospholipid antibodies, protein C, protein S, and antithrombin deficiencies, as well as factor V Leiden, prothrombin gene mutation G20210GA, and methylenetetrahydrofolate reductase C677T.
A total of 36 patients (23 men, 13 women, mean age, 64.8 years) diagnosed with colon ischemia were included in the study, as well as 18 patients with diverticulitis, and 52 healthy controls.
|72% of patients had prothrombotic abnormalities|
The results from the study show that the prevalence of antiphospholipid antibodies was significantly higher in patients with colon ischemia, compared with inflammatory and healthy controls (19.4% vs. 0% and 1.9%).
Among the genetic factors, only factor V Leiden was significantly associated with colon ischemia (22.2% vs. 0% and 3.8%).
A combination of thrombophilic disorders was found in 25% of the cases, and overall, one or several prothrombotic abnormalities were present in 26 patients (72%).
I.E. Koutroubakis, one of the co-authors of the report, concluded that the findings suggested that hereditary and acquired thrombotic risk factors might play an important role in the disease pathogenesis.