Dr Eleftheria Roma and coworkers investigated the diagnosis and treatment of peptic ulcer disease in children over a period that covers the recent changes in management of the disease.
2,550 children with upper GI symptoms underwent upper gastrointestinal endoscopy over a 9-year period. Only 52 (2%) were diagnosed with primary peptic ulcers. Of these, 10 were gastric ulcers and 52 duodenal.
The median age of children with duodenal ulcers was 10.5 years, compared to a median age of 6.5 years for gastric ulcers.
There was no significant difference between the symptoms of patients with or without ulcers
|European Journal of Pediatrics|
Helicobacter pylori infection was significantly higher in patients with duodenal ulcers (62%) than in patients with gastric ulcers (20%).
1 month after H. pylori eradication treatment, 19 children underwent repeat endoscopy. This showed ulcer healing in 95% of patients in failure to eradicate H. pylori in 27% of patients.
During long-term follow up 6 children became symptomatic, of which 2 had duodenal ulcer associated with H. pylori infection.
Dr Roma concludes, "Successful H. pylori eradication results in long-term healing of ulcers in children."