Microsatellite instability (MSI) describes a distinctive molecular pathway of carcinogenesis. Many sporadic gastric tumors are found to be positive for microsatellite instability.
Dr Domenico Palli and colleagues evaluated the role of dietary risk factors in 126 gastric cancer patients.
43 of the patients were found to have MSI-positive tumors. The remaining 83 were classified as MSI-negative.
|Types of food that increase risk of gastric tumors:|
- red meat
The researchers found that the risk of MSI-positive tumors was positively associated with red meat consumption. The risk was particularly high in patients with both high red meat consumption and a family history of cancer (odds ratio of 26).
Patients with increased white meat consumption showed reduced risk of MSI-positive tumors.
Certain foods had a significant protective effect against MSI-negative cancers. These included citrus fruit, garlic, vegetables, and olive oil. High intake of beta-carotene and sugar also reduced the risk of tumors.
In contrast, protein and sodium intake was positively associated with the risk of MSI-negative tumors.