An international team investigated the effect of HIV co-infection on progressive liver disease in people with hepatitis C virus (HCV).
The researchers, from the USA, China, and Australia, performed a meta-analysis to quantify any effect.
|HIV and HCV co-infection increase liver disease risk by 3-fold.
|Clinical Infectious Diseases|
Eight studies were identified that included outcomes of histological cirrhosis or decompensated liver disease.
It was found that, in the studies, HIV and HCV co-infection yielded a combined adjusted relative risk (RR) of 2.9.
Of note, studies that examined decompensated liver disease had a combined RR of 6.1.
Studies that examined histological cirrhosis had a pooled RR of 2.1
Author C. S. Graham, of the Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, concluded on behalf of the group, "There is a significantly elevated relative risk of severe liver disease in persons who are co-infected with HIV and HCV.
"This has important implications for timely diagnosis and consideration of treatment in co-infected persons."