The team investigated the relationship between the severity of reflux esophagitis (RE) according to the Los Angeles (LA) classification and esophageal motility.
They reported their findings in the April issue of the Journal of Gastroenterology.
28 healthy subjects and 48 reflux esophagitis patients (Grade A of the LA classification, 16 patients; Grade B, 16 patients; Grade C or D, 16 patients) were examined.
|LA classification of esophagitis mainly reflects esophageal clearance.
|Journal of Gastroenterology|
Esophageal manometry was performed by the intraluminal microtransducer method and resting lower esophageal sphincter (LES) pressure was assessed by the rapid pull-through method.
Esophageal contraction after 10 repeated 5 ml water swallowings, separated by 30 second intervals, was measured at 3, 8, 13, and 18 cm above the LES.
The researchers found that the resting LES pressure and the amplitude of esophageal contraction 3 cm above the LES in the Grades C and D group were significantly lower than those in the control group.
The amplitude of esophageal contraction 3 cm above the LES in the Grade B group was significantly lower than those in the Grade A group and the control group.
The frequency of failed peristalsis in the Grades C and D group were significantly higher than that in the controls and the Grade A and B groups.
Toshiaki Sugiura, of the Nippon Medical School, concluded on behalf of fellow authors, "The present findings suggested that the severity of reflux esophagitis according to the LA classification would be likely to mainly reflect esophageal volume clearance."