A team of researchers examined how medical conditions affect the risk of small-bowel adenocarcinoma (SBA).
A population-based European multi-center case-control study during the period 1995-97 was initiated.
95 histologically verified cases of SBA, along with 3,335 population controls were included.
Of these, 70 cases and 2,070 controls were interviewed about previous medical conditions.
Crohn's disease was identified in 2 SBA cases (both located in ileum), and 2 controls, with an odds ratio (OR) of 53.6. Only one case and no controls had had long-standing Crohn's disease.
|History of gallstones and gallstone surgery not associated with SBA.
|Scan J Gastroent|
Celiac disease was associated with SBA (2 cases, 0 controls), but one of the cases was diagnosed at the same time as the SBA.
Overall, people with a history of gallstones were found to have no increased risk of SBA.
The OR was exclusively increased during the 3-year period preceding the SBA diagnosis.
The researchers found that previous gallstone surgery, which may be a sign of severe gallstone disease, was not associated with SBA.
In addition, liver cirrhosis, hepatitis, or medical treatments with radioactive substances or corticosteroid tablets were not associated with this disease.
Cases with SBA were found to have an increased prevalence of anemia (OR, 15.3).
An association between low educational level and SBA was also found (OR, 1.8).
Author L. Kaerlev concluded on behalf of the group, "This study supports Crohn's disease and celiac disease being strong but rare risk factors for small-bowel adenocarcinoma.
"Previous gallstones were unrelated to SBA, and detection bias may account for the findings in earlier studies."