Women have lower glomerular filtration than men for the same serum creatinine value, not accounted for in model for end-stage liver disease.
Professor Andrew Burroughs and colleagues from the United Kingdom compared male vs female liver disease patients in model for end-stage liver disease (MELD) scores.
The team also compared creatinine, and glomerular filtration rates in these patients.
The research team undertook 403 creatinine measurements in 158 liver disease patients.
The team measured standard creatinine, O'Leary modified creatinine, and compensated creatinine Jaffe and enzymatic creatinine.
|There was a 2- or 3-point difference in female liver transplant candidates|
|American Journal of Transplantation|
The researchers assessed modified creatinine in 208 liver transplantation candidates.
In addition, the team evaluated EDTA-creatinine 51-glomerular filtration in 38 other candidates for liver transplantation.
The research team then derived a corrected creatinine.
The researchers calculated model for end-stage liver disease scores for measured and corrected creatinine in females.
Median creatinine and glomerular filtration in females were lower than males.
Both Modification of Diet in Renal Disease Study and EDTA-creatinine51 glomerular filtration rate were lower in females.
The team noted this difference despite lower creatinine values.
In females, the team noted that each model for end-stage liver disease score was lower than the corresponding model for end-stage liver disease-corrected creatinine.
The team found a 3-point difference in liver disease patients.
The researchers observed a 2- or 3-point difference in 65% of female liver transplantation candidates.
Professor Burroughs' team concluded, “Females with liver disease have lower glomerular filtration than males for the same creatinine value.
Correcting creatinine increases model for end-stage liver disease score by 2 or 3 points in 65% of female liver transplantation candidates.”
“Model for end-stage liver disease score adjustment in females would ensure equal liver transplantation priority by gender.”