Numerous studies examining the prevalence and natural history of dyspepsia in the general population have been conducted.
However, few have reported the effect of quality of life on the development of dyspepsia.
Dr Alexander Ford and colleagues from England conducted a 10-year longitudinal follow-up study examining the effect of quality of life on subsequent dyspepsia.
|28% developed new-onset dyspepsia at 10 years|
The team enrolled individuals originally in a population-screening program for Helicobacter pylori.
The subjects were contacted through a validated postal dyspepsia questionnaire.
The researchers assessed baseline demographic data, quality of life at original study entry.
The team found that dyspepsia and irritable bowel syndrome symptom data were already on file.
Consent to examine primary-care records was sought, and data regarding non-steroidal anti-inflammatory drugs and aspirin use were obtained from these.
The researchers found that of 8407 individuals originally involved, 3912 provided symptom data at baseline and 10-year follow-up.
Of 2550 individuals asymptomatic at study entry, 28% developed new-onset dyspepsia at 10 years, an incidence of 3% per year.
After multivariate logistic regression, lower quality of life at study entry, and higher body mass index were significant risk factors for new-onset dyspepsia.
The team observed that presence of irritable bowel syndrome at study entry was a risk factors for new-onset dyspepsia.
The team noted that use of non-steroidal anti-inflammatory drugs and/or aspirin was a significant risk factors for new-onset dyspepsia.
Dr Ford's team concluded, “The incidence of new-onset dyspepsia was almost 3% per year.”
“Low quality of life at baseline exerted a strong effect on the likelihood of developing dyspepsia at 10 years.”