Although hepatocellular carcinoma occurs with increased frequency in patients with primary biliary cirrhosis, the exact frequency is relatively low.
Optimal selection of primary biliary cirrhosis patients for hepatocellular carcinoma screening needs to be determined for effective screening.
Dr Keith Lindor and colleagues from Minnesota explored clinical predictors of hepatocellular carcinoma in primary biliary cirrhosis.
|Older age, and history of blood transfusion are clinical predictors|
|Clinical Gastroenterology & Hepatology|
The team performed a case-control study between 1976 and 2002.
The researchers evaluated 17 primary biliary cirrhosis patients with hepatocellular carcinoma identified at the Mayo Clinic.
Control primary biliary cirrhosis patients who had no evidence of hepatocellular carcinoma were selected for each case.
The team identified controls by matching the first year of their visit to the Mayo Clinic.
All medical information was collected within 2 years from when the cases were diagnosed with hepatocellular carcinoma.
The research team used logistic regression models for the analyses.
The researchers found that age, sex, and history of blood transfusion were associated with the presence of hepatocellular carcinoma.
The team noted that current smoking, and histologic stage at primary biliary cirrhosis diagnosis, were associated with the presence of hepatocellular carcinoma.
Any signs of portal hypertension, Mayo score, hemoglobin level, and platelet counts were associated with the presence of hepatocellular carcinoma.
In addition, the team noted that aspartate aminotransferase level, and albumin level were associated with hepatocellular carcinoma.
The researchers observed that older age, male sex, and history of blood transfusion increased the odds of hepatocellular carcinoma.
The team found that any signs of portal hypertension were associated with increased odds of hepatocellular carcinoma.
The research team observed that these markers yielded an excellent diagnostic performance.
Dr Lindor's team comments, "Older age, male sex, history of blood transfusion, and any signs of portal hypertension or cirrhosis indicate higher likelihood of hepatocellular carcinoma."
"These factors should be considered for hepatocellular carcinoma screening."
"Further studies in larger patient cohorts are required to verify the diagnostic model."