Dr Jan De Waele and colleagues assessed a scoring system based on signs of systemic inflammation on computed topography as an early prognostic tool in acute pancreatitis.
The team evaluated 40 patients with acute pancreatitis who received an abdominal computed tomography within 24 hours after admission.
The Balthazar score, computed tomography severity index, and ExtraPancreatic Inflammation on computed scores were calculated for all patients.
The ExtraPancreatic Inflammation on computed scores were based on the presence of pleural effusion, ascites, and retroperitoneal fluid collections.
The team's end points were the occurrence of severe acute pancreatitis, and in hospital mortality.
|An ExtraPancreatic Inflammation on computed score over 4 had 100% sensitivity|
The researchers evaluated this score by calculating receiver operator characteristic curves.
The score was also evaluated by calculating the area under the receiver operator characteristic curve.
The researchers found that the mean age of the patients was 50 years, and the Ranson score was 3.
The team observed that 35% of patients developed severe disease, and in hospital mortality was 15%.
The mean ExtraPancreatic Inflammation on computed score was about 4.
The area under the receiver operator characteristic curve for predicting severe disease and mortality was 0.9 and 0.85, respectively.
The team noted that an ExtraPancreatic Inflammation on computed score over 4 had 100% sensitivity, and 71% specificity for predicting severe pancreatitis.
The score was superior to the Balthazar score and computed tomography severity index in predicting outcome.
Dr De Waele‘s team concludes, “Extrapancreatic inflammation assessed by abdominal computed tomography scan, and quantified with the ExtraPancreatic Inflammation on computed score accurately estimates acute pancreatitis disease severity and mortality within 24 hours of admission.