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 26 May 2018

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News

Hep C outcomes vary according to virus type

Among the Hep C virus RNA-positive infections, type 1 infection may be more aggressive than types 2 or 3, finds this month's Journal of Viral Hepatitis.

News image

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Whether differences in the natural history of Hepatitis C virus can be explained by differences in the infecting Hepatitis C type is unknown.

Dr Helen Harris and colleagues from England investigated whether the Hepatitis C type might influence the clinical outcome of infection.

Study serum samples were assembled from 749 individuals.

The individuals enrolled into the United Kingdom Hepatitis C National Register from which data on clinical outcomes were extracted.

Hepatitis C virus-RNA-positive specimens were genotyped and Hepatitis C virus-RNA-negative specimens serotyped.

69% with Hep C virus type 1 had cleared infection
Journal of Viral Hepatitis

The research team used logistic regression analysis to investigate the independent effect of Hepatitis C type on viral clearance.

The team compared 86 patients who were Hepatitis C virus RNA negative with 508 who were Hepatitis C virus RNA positive.

The researchers used the same method to investigate whether Hepatitis C virus type was associated with histological stage of liver disease.

The prevalence of Hepatitis C virus type 1 among those who cleared infection was 69%.

The team found that among those who remained Hepatitis C RNA positive the infection clearance rate was 51%.

Type 1 infections were more likely to be Hepatitis C virus RNA negative than non-1 types.

The researchers noted that type 1 infections were also more likely to be associated with histological stage scores above the median when compared with non-1 types.

Dr Harris' team concludes, “Hepatitis C virus type 1 infection was more often Hepatitis C virus RNA negative.”

“This suggests that spontaneous clearance may occur more commonly with this type.”

“Among the RNA-positive infections, type 1 infection may be more aggressive than types 2 or 3.”

J Vir Hep 2007: 14(3): 213-20
20 February 2007

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