Impaired butyrate oxidation, and raised sulfate-reducing bacteria in the colon indicates that ulcerative colitis may be induced by hydrogen sulfide toxicity.
Dr Singh and colleagues from England examined enzymatic removal of H2S in erythrocytes and colonic mucosa from subjects with ulcerative colitis and Crohn's disease.
Rhodanese and thiol methyltransferase activities were measured in rectal mucosa and erythrocytes, and plasma thiocyanate was determined.
The investigative team analyzed 4 groups.
Group 1 included patients with ulcerative colitis, and Group 2 had patients with Crohn's disease.
|Control levels of rhodanese were higher in men than in women|
|Digestive Diseases and Sciences|
Group 3 included hospital controls, which were patients with dyspepsia or irritable bowel syndrome, and Group 4 consisted of healthy volunteers.
The team noted that rhodanese and thiol methyltransferase activity in rectal biopsies did not differ between the groups.
The investigators found that control levels of rhodanese were higher in men than in women.
In erythrocytes, rhodanese activity was significantly higher in ulcerative colitis patients than in hospital or volunteer controls.
The team observed that thiol methyltransferase activity was higher in erythrocytes from ulcerative colitis patients and hospital controls vs volunteer controls.
Dr Singh's team commented, “We found no evidence of defective enzymic detoxication of sulfide by rhodanese or thiol methyltransferase in patients with ulcerative colitis or Crohn's disease.”