Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 23 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Balloon-based endoscopic ablation can eliminate Barrett's

Circumferential ablation of Barrett's using balloon-based endoscopic radiofrequency eliminates the disease in the majority of patients, shows February's Gastrointestinal Endoscopy.

News image

fiogf49gjkf04

Dr Virender Sharma and colleagues from Arizona assessed the dose-response, safety, and efficacy of circumferential endoscopic ablation of Barrett's esophagus.

The researchers used an endoscopic balloon-based ablation device that delivered a pre-set amount of energy density to Barrett's tissue.

The researchers conducted the study in 2 serial phases at 8 centers between 2003 and 2005.

The first phase included the dosimetry phase, which evaluated the dose-response and the safety of delivering 6 to 12 J/cm2 in 32 patients.

The second was the effectiveness phase, and used 10 J/cm2 in 70 patients.

There was a complete response for Barrett's in 70% of patients
Gastrointestinal Endoscopy

The procedures were delivered twice for all patients, followed by EGD with biopsies at 1, 3, 6, and 12 months.

The researcher performed a second ablation procedure if Barrett' esophagus was present at 1 or 3 months.

Patients received esomeprazole 40 mg twice a day for 1 month after ablation, and 40 mg every day thereafter.

The team quantified postablation symptoms by using a 14-day symptom diary.

The researchers defined a complete response as all biopsy specimens negative for Barrett's esophagus at 12 months.

Patients were 18 to 75 years of age, with a diagnosis of Barrett's esophagus and without dysplasia.

The patients had histopathology reconfirmation of the diagnosis within 6 months of enrollment.

Median symptom scores returned to a score of 0 of 100 by day 3 in the dosimetry phase.

The team observed no dose-related serious adverse events.

The outcomes at 1 and 3 months permitted the selection of 10 J/cm2 for the subsequent effectiveness phase of the study.

During the effectiveness phase, the team noted that median symptom scores returned to a score of 0 of 100 by day 4.

At 12 months, the researchers achieved a complete response for Barrett's esophagus in 70% of patients.

The researchers found no strictures, and no buried glandular mucosa in either study phase.

Dr Sharma's team concludes, “Circumferential ablation of nondysplastic Barrett's esophagus by using this balloon-based ablation device can be performed with no subsequent strictures or buried glands.

“This method completely eliminates Barrett's esophagus in 70% of patients at 1-year follow-up.”

Gastrointest Endoscopy 2007: 65(2): 185-95
07 February 2007

Go to top of page Email this page Email this page to a colleague

 23 November 2017 
Distance travelling for rectal cancer outcomes
 23 November 2017 
Incidence of biopsy-verified celiac disease
 23 November 2017 
Pharmacological management of GERD
 22 November 2017 
Surgical treatment delays influence survival in colon cancer
 22 November 2017 
Golimumab in Crohn's disease
 22 November 2017 
Challenges of US-trained gastroenterologists when abroad
 21 November 2017 
Prepregnancy obesity and maternal mortality
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 15 November 2017 
Medication nonadherence and health care costs
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Heartburn relief in adolescents with GERD
 01 November 2017 
Autoimmune pancreatitis in children
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's
 26 October 2017 
Conversion to open laparotomy in rectal cancer
 25 October 2017 
Conversion of colonoscopy to sigmoidoscopy
 25 October 2017 
Rifaximin and survival in hepatic encephalopathy

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us