Celiac disease is an important cause of hypertransaminasemia.
Celiac disease might also be associated with severe forms of liver disease.
The Jonas Ludvigsson and colleagues investigated the risk of liver disease in 13,818 patients with Celiac disease from 1964 to 2003.
The investigative team reported that 66,584 age- and sex-matched reference individuals from a general population cohort.
The investigators used Cox regression to estimate hazard ratios for later liver disease.
|Prior liver disease has a 4- to 6-fold increased risk of celiac disease|
|Clinical Gastroenterology & Hepatology|
The team used conditional logistic regression to estimate the risk of celiac disease in individuals with liver disease before study entry.
Celiac disease was associated with an increased risk of acute hepatitis, chronic hepatitis, and primary sclerosing cholangitis.
The investigators noted that fatty liver, and liver failure were associated with an increased risk of acute hepatitis.
The team found that liver cirrhosis or liver fibrosis, and primary biliary cirrhosis were associated with an increased risk of acute hepatitis.
There was no increased risk of liver transplantation.
The investigative team observed that adjustment for socioeconomic index or diabetes mellitus had no notable effect on the risk estimates.
Prior liver disease was associated with a statistically significant 4- to 6-fold increased risk of later celiac disease.
Dr Ludvigsson's team concludes, “This study suggests that individuals with celiac disease are at increased risk of both prior and subsequent liver disease.”