Earlier studies have suggested that untreated celiac disease may be associated with osteoporosis.
However, results are contradictory for the risk of long-term fractures.
Dr Ludvigsson and colleagues from Sweden studied the association between celiac disease and fractures.
The researchers used Cox regresson to examine the future risk of hip fracture and fracture of any type in more than 13,000 individuals with celiac disease.
The team assessed 65,000 age- and sex-matched reference individuals in a general population-based cohort.
During follow-up, 1365 first hip fractures and 4847 fractures of any type occurred.
|The excess risk of hip fractures was 4 per 100,000 person-years|
|Alimentary Pharmacology & Therapeutics|
The research team observed that celiac disease was positively associated with hip fracture, and fractures of any type.
The researchers found that the absolute excess risk of hip fractures in children with celiac disease was 4 per 100,000 person-years.
The team noted that incidence ratios for hip fracture in individuals with celiac disease were about 2.
These occured prior to diagnosis of celiac disease and afterwards.
The team observed that the increase in risk remained 20 years after diagnosis of celiac disease.
Dr Ludvigsson's team concludes, “Individuals with celiac disease, including children with celiac disease, may be at increased risk of hip fracture and fracture of any type.”
“Celiac disease may be positively associated with long-term hip fracture risk.”