The gap between the demand for liver transplantation and organ donation rates has a major impact on waiting list mortality.
Understanding the risk factors that predict liver transplant waiting list death may help optimize organ allocation policy and reduce waiting list deaths.
Dr Michael Fink and colleagues from Australia analyzed risk factors associated with waiting list mortality in the Liver Transplant Unit Victoria from 1988 and 2004.
The researchers showed that the mean annual waiting list mortality for the period examined was 10% for adult, and 6% for pediatric patients.
|A model for end-stage liver disease score of 20 was associated with waiting list death|
|Journal of Gastroenterology & Hepatology|
Factors associated with waiting list death included female sex, fulminant hepatic failure, primary non-function, blood group O.
More urgent United Network for Organ Sharing-derived medical status, and a Child-Turcotte-Pugh score of 11 was associated with waiting list death.
The team found that a model for end-stage liver disease score of 20 was associated with waiting list death.
In addition, the researchers identified that a pediatric end-stage liver disease score of 20 was associated with waiting list death.
Dr Fink's team commented, “Disease severity scores, such as model for end-stage liver disease, predict the risk of liver transplantation waiting list mortality.”
“Use of such scores in organ allocation in liver transplant units may result in reduced waiting list mortality.”