Dr Sari Tikkakoski and colleagues from Finland evaluated the nutritional parameters of individuals with a previous diagnosis of celiac disease.
The investigative team compared the results with those of screen-detected patients in a large cohort of adults in primary care.
The investigators screened 1900 adults, aged 18 to 64 years, for tissue transglutaminase antibodies in primary care.
Immunoglobulin A-endomysium antibodies, HLADQ2/8 associated with celiac disease were determined in positive individuals.
|33% of the screen-detected celiac disease patients were obese|
|Scandanavian Journal of Gastroenterology|
Folate, iron, and transferrin receptor in sera were assessed in patients reporting a previous diagnosis of celiac disease and patients positive for the above tests.
The investigative team found that 1% of patients reported a previous diagnosis of celiac disease.
Among the screen-detected cases with transglutaminase antibodies, 14 of 32 cases had celiac disease.
This was based on high levels of transglutaminase antibodies, and immunoglobulinA-endomysium antibodies, DQ2/8 genotype or biopsy results.
The investigators found that the prevalence of celiac disease was as high as 1:53 in the total study population, and in women it was 1:46.
Nutritional deficiencies were rare among celiac disease patients diagnosed earlier but common among those who had an undiagnosed celiac disease.
The team observed that 33% of the screen-detected celiac disease patients were obese.
The investigators noted that screen-detected patients did not present more abdominal symptoms than those with no celiac disease.
Dr Tikkakoski's team concludes, “Celiac disease is common, the proportion among women possibly being as high as 2%.”
“Although the great majority of screen-detected patients do not present any gastrointestinal symptoms at primary care, nutritional deficiencies such as low folate levels and iron deficiency are common.”