Controversy exists as to whether people with primary biliary cirrhosis have an increased risk of developing osteoporosis.
There is addition controversy to which extent an increased risk of osteoporosis in these patients may translate into an increased risk of fracture.
Dr Masoud Solaymani-Dodaran and colleagues performed a cohort study to quantify the excess fracture risk in people with primary biliary cirrhosis.
The research team identified 930 people with primary biliary cirrhosis using the General Practice Research Database.
The patients further identified 9202 age- and sex-matched control subjects.
The researchers used Cox regression to estimate the hazard ratios for any fracture, hip fracture, and ulna/radius fracture in the primary biliary cirrhosis cohort.
The team compared these results with the general population.
|Absolute excess risk in for any fracture was 13 per 1000 person-years|
The researchers found a 2-fold relative increases in the risk of any fracture, hip fracture, and ulna/radius fracture for the primary biliary cirrhosis cohort.
The absolute excess risk in for any fracture was 13 per 1000 person-years, and 2 per 1000 person-years for hip fractures.
The research team noted that the absolute excess in risk for ulna/radius fracture was 3 per 1000 person-years.
In those people with more severe disease, the relative risks of fracture were similar.
Dr Solaymani-Dodaran's team concludes, “There are modest increases in both the absolute and relative fracture risks in people with primary biliary cirrhosis compared with the general population, with the excess risks similar in those with more severe disease.”