The impact of enteral nutrition on post-operative recurrence has not been properly examined.
Dr Yamamoto and colleagues from Japan investigated the impact of enteral nutrition using an elemental diet, on clinical and endoscopic recurrence after resection for Crohn's disease.
The team of doctors studied 40 consecutive patients who underwent resection for ileal or ileocolonic Crohn's disease.
After operation, 20 patients continuously received enteral nutritional therapy in Group 1.
|Only 5% on enteral therapy developed clinical recurrence|
|Alimentary Pharmacology & Therapeutics|
Group 2 included 20 patients who had neither nutritional therapy nor food restriction.
In Group 1, enteral formula was infused through a nasogastric tube in the night-time, and low fat foods were taken in the daytime.
The doctors followed up all patients regularly for 1 year after operation.
Ileocolonoscopy was performed at 6 and 12 months after operation.
The team found that 5% in Group 1, and 35% in Group 2 developed clinical recurrence during 1-year follow-up.
The doctors noted that 6 months after operation, 25% in Group 1, and 40% in Group 2 developed endoscopic recurrence.
At 12 months after the operation, the team observed endoscopic recurrences in 30% of patients in Group 1, and 70% in Group 2.
Dr Yamamoto's team concluded, “Our long-term enteral nutritional therapy significantly reduced clinical and endoscopic recurrence after resection for Crohn's disease.”