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 20 November 2017

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News

Younger diagnosis of Crohn's has a poorer prognosis

Patients diagnosed younger with Crohn's have worse prognosis than those diagnosed later in life, shows the latest Alimentary Pharmacology & Therapeutics.

News image

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Dr Canavan and colleagues from England investigated the incidence of death in patients diagnosed with Crohn's disease over 20 years ago.

The research team evaluated the Cardiff database of patients with Crohn's disease.

The database contains data on all patients diagnosed there since 1934.

The researchers traced 394 patients diagnosed before 1985, and established their mortality status in 2004.

The overall standardized mortality ratio was 1.3.

The team noted that the standardized mortality ratio has not significantly changed since the 1970s.

Median age at death is 58 years if diagnosed at 10 to 26 years
Alimentary Pharmacology & Therapeutics

The researchers found that the standardized mortality ratio decreased with age, from about 17 for patients aged 10 to 19 years to 0.9 in those over 75 years.

Kaplan-Meier analysis of age at death shows that patients diagnosed aged 10 to 26 years have median age at death of 58 years.

The researchers observed that those aged 27 to 52 years have a median age death of 66 years.

In addition, the team noted that those aged 53 to 58 years have a median aged death of 74 years, and those over 59 years of 79 years.

Dr Canavan's team concludes, “Our study shows a significantly raised standardized mortality ratio, not statistically changed since the 1970s and similar to other chronic conditions.”

“Patients diagnosed younger have worse prognosis than those diagnosed later in life and a reduced life expectancy compared with the general population.”

Aliment Pharm Ther 2006: 25(1): 59
13 December 2006

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