Dr Pierre Nahon and colleagues from France estimated the additional value of liver stiffness measurement in the assessment of fibrosis.
The research team compared these results with physicians' assessment of fibrosis based on epidemiological, clinical, and biological parameters.
The researchers evaluated 142 unselected patients with chronic Hepatitis C.
Liver biopsy and liver stiffness measurement were performed simultaneously.
There were 4 physicians that independently predicted the stage of fibrosis.
The stage of fibrosis was determined according to the METAVIR classification, an algorithm for the grading of activity in chronic Hepatitis C.
The physicians used clinical, epidemiological, and biological data.
For the second step, the physicians were informed of liver stiffness measurement values and could modify their first evaluation if necessary.
Finally, the researchers compared the 2 successive evaluations with the histological fibrosis score.
|Assessment improved in 3 of the 4 physicians|
|American Journal of Gastroenterology|
The researchers found that providing liver stiffness measurement values improved agreement between physicians.
The team noted that it resulted in a better correlation between clinical impression and histological liver fibrosis.
The diagnostic performances were only significantly improved with transient elastography for the diagnosis of cirrhosis.
The team found that in these cases, assessment improved in 3 of the 4 physicians.
In addition, these performances were nearly similar for junior and senior physicians when liver stiffness measurement was provided.
Dr Nahon's team concludes, “Providing liver stiffness measurement values to physicians results in a better estimation of liver fibrosis and a more accurate diagnosis of cirrhosis.”
“Moreover, it allows physicians with limited experience to predict liver fibrosis as well as experienced hepatologists.”