Dr Victor de Lédinghen and colleagues from France described the natural history of a Hepatitis C infection outbreak.
The outbreak occurred in 196 patients who had sclerotherapy by the same physician.
The researchers evaluated the patients to confirm patient-to-patient transmission using phylogenetic analysis in a large series of patients.
Demographic information included clinical and biological parameters.
The research team performed fibrosis evaluation using liver biopsy or transient elastography.
Follow-up was maintained until death, or the end of the observation period.
The researchers also determined if the virus had been transmitted between the Hepatitis C genotype 2 patients.
|44% had significant fibrosis|
|Journal of Hepatology|
This was done by sequence analysis of a part of the NS5b region of the genomes in samples of patients.
The mean duration of follow-up was 23 years.
The researchers found that in patients with fibrosis evaluation, 56% had no or mild fibrosis and 44% had significant fibrosis.
The team noted that no patient died from Hepatitis C-related disease.
Nucleotide sequence analysis of a part of the NS5b region revealed that patients were all infected with the same Hepatitis C subtype, genotype 2d.
The team observed that the most evident feature of the tree is the clustering of all patients involved in the outbreak without any unrelated isolates.
Dr Lédinghen's team comments, “This study emphasizes the risk for nosocomial spread of Hepatitis C virus during intravenous therapy.”