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 18 November 2017

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News

GERD is one of the risk factors of peptic strictures

Prior GERD, hiatus hernia, and peptic ulcer are associated with an increased risk of peptic stricture, shows the latest American Journal of Gastroenterology.

News image

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Dr Ana Ruigómez and colleagues from Spain determined the incidence, natural history, and recurrence rate of esophageal stricture diagnosed in primary care.

The researchers identified patients with a stricture diagnosis from the United Kingdom General Practice Research recorded between 1994 and 2000.

Diagnoses were confirmed by general practitioner-completed questionnaires.

Patients with stricture were compared to an age- and sex-matched sample of controls from the original source population.

The researchers estimated the incidence of stricture, potential risk factors, and comorbidities.

68% of stricture cases were peptic
American Journal of Gastroenterology

The team also calculated the relative risk for subsequent stricture recurrence and mortality.

The researchers found that the incidence of esophageal stricture was 1 per 10,000 person-years, and increased markedly with age.

Incidence of stricture decreased from 1994 to 2000, concomitant with a substantial increase in proton pump inhibitor (PPI) use.

The researchers noted that 68% of stricture cases were peptic.

The team observed that prior dysphagia, gastroesophageal reflux disease (GERD), and hiatus hernia were associated with an increased risk of stricture.

In addition, peptic ulcer disease, and heavy alcohol use were associated with an increased risk of stricture.

The rate of stricture recurrence was 11 per 100 person-years.

Risk of recurrence associated with long-term PPI use adjusting for other factors was 0.6.

Mortality in patients with peptic stricture was similar to that in the control population.

Dr Ruigómez's team commented, “Esophageal stricture is a rare event, and most cases in primary care are peptic strictures.”

“Prior GERD, hiatus hernia, and peptic ulcer are associated with an increased risk of peptic stricture.”

“Incidence of stricture decreased from 1994 to 2000.”

Am J Gastroenterol 2006: 101(12): 2685
07 December 2006

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