Disturbance of gastric emptying leads to a variety of symptoms.
In addition, gastric motility disorders might play a role in the pathophysiology of functional dyspepsia.
In previous studies 13C breath tests were validated as non-invasive tools in the measurement of gastric emptying time.
So far, reliable reference values of healthy subjects are missing and the impact of constitutional traits needs to be clarified.
Dr Stephan Hellmig and colleagues from Germany conducted a study in 90 healthy individuals.
The research team assessed the correlation of parameters of gastric emptying with age, sex and body mass index for fluid and solid test meals by 13C breath tests.
The researchers used 100 mg of sodium acetate or sodium octanoate, respectively, as tracers.
|Median half gastric emptying time for solids was 127 min|
|Journal of Gastroenterology & Hepatology|
Breath probes were analyzed by non-dispersive infrared spectroscopy.
The team determined that mean of half gastric emptying time of a fluid test meal was 81 minutes and for fastest gastric emptying time to be 40 min.
However, the half and fastest gastric emptying time of solid meals did not fit to normal distribution, and median and percentiles were determined instead.
The researchers found that the median time of half gastric emptying for solids was 127 min, and 82 min for fastest gastric emptying time.
The team observed no significant correlation between gastric emptying and age, sex or body mass index.
Dr Hellmig's team concludes, “This is the first study to examine gastric emptying in an adequate number of healthy subjects by 13C breath tests.”
“No significant correlation was found with age, sex and body mass index.”
“Although there is considerable standard deviation in gastric emptying time, these results may nevertheless serve as reference values for further studies.”