The diagnostic and therapeutic relevance of CARD15 genotyping in Crohn's disease for daily clinical practice has not been investigated so far.
Dr Julia Seiderer and colleagues analyzed whether CARD15 variants are independent predictive factors for small bowel stenosis in Crohn's.
Small bowel stenosis was evaluated by magnetic resonance enteroclysis.
On the basis of these findings, the potential implications for patient management were investigated.
The research team included 80 patients with Crohn's disease and clinical symptoms suggestive of small bowel stenosis.
|62% with a CARD15 variant were diagnosed with intestinal stenosis|
|Inflammatory Bowel Diseases|
All patients were genotyped for CARD15 variants, and examined by magnetic resonance enteroclysis of the small bowel.
The researchers found CARD15 variants in 50% of patients.
Magnetic resonance enteroclysis identified 38% of patients with small bowel stenoses.
About 62% of patients with at a CARD15 variant were diagnosed with intestinal stenosis by magnetic resonance enteroclysis.
The researchers observed that the presence of the 1007fs variant was associated with an increased risk of an intestinal stenosis.
The research team noted that 68% of patients with stenoses required surgical intervention, with 62% patients carrying the 1007fs variant.
Dr Seiderer's team concludes, “We conducted the largest prospective study analyzing the diagnostic value of CARD15 variants in Crohn's disease patients performed so far.”
“We identified the 1007fs variant as strong predictor for intestinal stenoses with need for surgery in Crohn's disease patients.”
“Genotyping could therefore be an important diagnostic tool in clinical practice for identifying high-risk patients with specific diagnostic and therapeutic needs.”
“Moreover, magnetic resonance enteroclysis is an excellent technique for diagnosing small bowel stenoses.”