Dr Geoffroy Vanbiervliet and colleagues determined the diagnostic accuracy of C-reactive protein for alcoholic hepatitis in heavy drinkers.
A total of 101 heavy drinkers with elevated transaminase activity were included in the study.
The participants also had negative Hepatitis B surface antigen, anti-Hepatitis C and anti-human immunodeficiency virus (HIV) antibodies.
All patients underwent standard liver function tests, C-reactive protein determination, and liver biopsies.
|Pathological signs of alcoholic hepatitis were found in 30%|
|Scandanavian Journal of Gastroenterology|
The investigators reported that none of the patients had signs of infection or inflammatory disease, and none of them were taking antibiotics.
The severity of alcoholic hepatitis was assessed semi-quantitatively using a Metavir-derived scoring system.
The receiver operating curve for C-reactive protein was constructed to assess different areas under the curve.
The investigators used the receiver operating curve, and the best threshold value for predicting alcoholic hepatitis.
Pathological signs of alcoholic hepatitis were found in 30%, and significant fibrosis 45% of patients.
The investigative team found that C-reactive patients increased significantly with the severity of acute alcoholic hepatitis.
Total bilirubin, and C-reactive protein were independent factors for predicting alcoholic hepatitis.
The team noted that area under the receiver operating curve curve of C-reactive protein was 0.8.
The sensitivity, specificity, positive, negative predictive value and diagnostic accuracy were 41%, 99%, 92%, 81% and 82%, respectively.
Dr Vanbiervliet's team concludes, “C-reactive protein is an accurate marker of alcoholic hepatitis.”