The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion.
Dr Steven Kliewer showed that fibroblast growth factor-15.
|A postprandial timing mechanism controls gallbladder motility
Growth factor hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling.
The researchers demonstrated that gallbladder filling is actively regulated by an endocrine pathway.
Dr Kliewer's team concludes, “We suggest a postprandial timing mechanism that controls gallbladder motility."