Obesity has been associated with increased reporting of gastrointestinal (GI) symptoms, but whether weight gain or loss causes symptoms is unclear.
Dr Cremonini and colleagues from Minnesota studied the association between changes in body weight and upper gastrointestinal symptoms.
The research team conducted a prospective cohort study on random samples.
The team defined distinct upper gastrointestinal symptom complexes.
These included gastro-esophageal reflux disease, chest pain, dyspepsia- pain predominant, dyspepsia-dysmotility.
|There was no association with a weight loss greater than 10 lb|
|Neurogastroenterology & Motility|
The researchers identified subjects with persistent, new-onset or disappearing symptoms as cases.
Subjects with no reported symptoms in any of the surveys served as controls.
Associations were studied in a logistic regression model, using age, gender, baseline body mass index and somatic symptom score as covariates.
There were 637 participants for whom baseline and follow-up data were available.
The median time between surveys of 11 years.
The team found that baseline body weight was associated with gastro-esophageal reflux disease, chest pain and dyspepsia-pain predominant symptom complexes.
The researchers noted that an increase in body weight greater than 10 lb between surveys was associated with new onset of dyspepsia-dysmotility.
Dr Cremonini's team concludes, “No association was found between weight loss greater than 10 lb and the studied symptom complexes.”
“Moderate body weight increases and decreases are generally not associated with upper gastrointestinal symptom changes over time in the general population.”