As opposed to regular C-reactive protein assays, the introduction of high-sensitivity ones detects low grade inflammation in patients with inflammatory bowel disease (IBD).
Dr Shlomo Berliner and colleagues from Israel evaluated the degree of correlation between high-sensitivity C-reactive protein levels and the inflammatory IBD activity score.
The researchers included 90 patients with Crohn's disease, 70 with ulcerative colitis, and 160 controls.
Disease activity was determined using Crohn's disease activity index for Crohn's disease and Mayo score for ulcerative colitis.
| High-sensitivity C-reactive protein assay estimates IBD disease activity in daily practice|
The research team used the Dade Boering BNII Nephelometer to determine the high-sensitivity C-reactive protein concentrations.
The team found that the coefficient of correlation between C-reactive protein and disease activity score was similar for ulcerative colitis and Crohn's.
Dr Berliner's team concludes, “These findings are relevant for therapeutic intervention.”
“Greater absolute reduction in the high-sensitivity C-reactive protein concentration in Crohn's disease patients might be interpreted as a better response compared to the same absolute reduction in ulcerative colitis patients.”
“This information is needed for clinicians using the high-sensitivity C-reactive protein assay to estimate IBD disease activity in daily practice.”