Limited data exist on the proportion of drug-induced liver injury among out-patients seen in a hepatology clinic.
Dr de Valle and colleagues from Sweden determined the proportion of drug-induced liver injury cases.
The investigative team identified the most important agents and the nature of the liver injury.
The team analyzed a computerized diagnoses database in an out-patient hepatology clinic in a Swedish University hospital from 1995 to 2005.
All suspected drug-induced liver injury cases were causality assessed with the International Consensus Criteria.
A total of 1164 cases were seen for the first time during this period.
The team found drug-induced liver injury with at least a possible causal relationship in 7% of cases.
|Drug-induced liver injury cases constituted 6% of all out-patients|
|Alimentary Pharmacology & Therapeutics|
Of these, 3% were referred for evaluation to the out-patient clinic whereas 3% had a follow-up after hospitalization of drug-induced liver injury.
The median age was 58 years, and 56% were females.
The investigators observed a hepatocellular pattern in 48%, cholestatic in 40% and mixed in 12% of cases.
The team noted that antibiotics were the most common agents causing drug-induced liver injury followed by non-steroidal anti-inflammatory drugs.
Diclofenac most often responsible for the drug-induced liver injury.
Dr de Valle's team concludes, “Drug-induced liver injury cases constituted 6% of all out-patients and 3% of referrals and occurred more often in women.”
“Antibiotics and diclofenac were the most common causes of drug-induced liver injury among out-patients.”