Pancreatic adenocarcinoma has been associated with several familial cancer syndromes that also predispose to other malignancies.
Younger ages of onset of pancreatic cancer have been reported in families with these syndromes.
Dr Robert McWilliams and colleagues from Minnesota evaluated 624 consecutive patients from the Mayo Clinic Pancreatic Cancer Patient Registry.
The patients completed questionnaires, and were analyzed for family history of cancer and cigarette smoking.
The ages at diagnosis of those patients who reported a family history of pancreatic cancer, breast, ovarian, colorectal cancer, or melanoma were compared with those who did not.
|A family history of breast, ovarian, colorectal cancers were risk factors|
|Clinical Gastroenterology & Hepatology|
The research team performed multivariable regression analyses with age at diagnosis as the primary outcome variable.
As the team expected, smokers had a younger median age of onset of pancreatic cancer than nonsmokers in dose-dependent fashion.
After controlling for tobacco exposure and gender, those patients with a family history of breast, ovarian, colorectal cancers, and melanoma had a younger age of onset of pancreatic cancer.
The team found that those with a family history of pancreatic cancer exhibited no difference.
The researchers observed that patients reporting other cancers in relatives showed no difference in age of onset of pancreatic cancer.
Dr McWilliams' team concludes, “A family history of cancers associated with specific cancer syndromes that are known to contribute also to pancreatic cancer risk is associated with a younger onset of pancreatic cancer.”
“A family history of pancreatic cancer does not appear to affect age of onset of pancreatic cancer.”