In patients with unexplained elevated transaminases, prognosis of the liver disease are unknown.
Factors associated with increased risk of liver fibrosis and normal/subnormal liver are also not known.
Dr Victor de Lédinghen and colleagues from France identified diagnosis and clinical and biological factors associated with significant fibrosis.
The research team also assessed minimal lesions of the liver in patients with persistent unexplained elevated alinine amino transferase levels.
The team evaluated all consecutive asymptomatic patients with unexplained chronically elevated alinine amino transferase levels from 2002 to 2004.
All patients had clinical, biological, ultrasonographic examination and a liver biopsy.
|Significant fibrosis was found in 27% of patients|
|Journal of Hepatology|
The researchers assessed a total of 272 patients, of which 60% were males with a mean age of 46 years and a body mass index of 27.
The team found minimal lesions in 19% of patients, steatosis in 27%, non-alcoholic steatohepatitis in 33%, and miscellaneous pathology in 22%.
Significant fibrosis was found in 27% of cases, including 9 cases of cirrhosis.
By multivariate analysis, the team found that independent predictors of significant fibrosis were tobacco use, a body mass index above 25, and diabetes.
Independent factors associated with minimal lesions were female gender, and a body mass index below 25.
Dr Lédinghen's team concluded, “In patients with unexplained
chronically elevated transaminases, significant fibrosis is associated with
tobacco use, a body mass index above 25 and diabetes.”
“Minimal lesions are significantly associated with female gender and body mass index below 25.