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 25 November 2017

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News

Quality of life improves in the first year from IBD diagnosis

This month's Inflammatory Bowel Diseases reports that health-related quality of life improves during the first year from diagnosis in Crohn's and ulcerative colitis.

News image

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Health-related quality of life is of increasing importance in the evaluation of new therapies for inflammatory bowel disease (IBD).

Available data concerning health-related quality of life in pediatric patients are sparse and uniformly cross-sectional.

Dr Anthony Otley and colleagues described quality of life and influential factors in newly diagnosed pediatric patients with Crohn's and ulcerative colitis.

The research team assessed the patients during the first 12 months after diagnosis.

The team drew participants from a large, prospectively derived observational IBD registry of pediatric patients studied through 18 USA and Canadian centers.

Mean IMPACT scores decreased with increasing age
Inflammatory Bowel Diseases

Patients who had completed a baseline IMPACT questionnaire and for whom there were 12 months of follow-up data available were included.

In addition to description of cohort, the team evaluated factors that were believed to influence health-related quality of life from diagnosis.

The researchers reported that 218 children met inclusion criteria.

Of these, 77% had Crohn's disease, and 23% had ulcerative colitis with a mean age of 13 years.

The team noted that the mean total IMPACT score at baseline was 154, 181 at 6 months, and 191 at 1 year.

Increasing scores represented better quality of life.

Repeated measures analysis showed that age and disease severity significantly negatively affected the IMPACT scores during the course of the year.

Dr Otley's team concluded, “In this large prospective pediatric inflammatory bowel disease cohort, significant improvement in health-related quality of life is noted during the year from diagnosis.”

“Mean IMPACT scores varied significantly depending on the disease severity and also decreased with increasing age.”

Inflamm Bowel Dis 2006: 12(8): 684-91
28 August 2006

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