The prevalence and significance of joint symptoms appearing in patients with ulcerative colitis following a colectomy are unclear.
Dr Mitsuhiro Nakamura and colleagues from Japan retrospectively reviewed medical records of 571 patients.
The patients underwent an ileal pouch-anal anastomosis with a mucosectomy.
The researchers investigated joint symptoms during steroid tapering following an ileal pouch-anal anastomosis and the cumulative risk for developing pouchitis.
A diagnosis of pouchitis was obtained using the Pouchitis Disease Activity Index.
|Joint symptoms during steroid tapering occurred in 22% of ulcerative colitis patients|
The team estimated the cumulative risk of pouchitis using a Kaplan-Meier life table analysis.
The researchers reported joint symptoms during steroid tapering by 22% of the ulcerative colitis patients.
Each of these patients had involvement of the small joints of the hand.
The team found that the main symptoms were pain and stiffness, especially in the morning.
The cumulative risk for developing pouchitis after 10 years was found to be 20% in patients who experienced joint symptoms during steroid tapering.
The researchers found that the cumulative risk for pouchitis was 10% in those without those symptoms.
Dr Nakamura's team concluded, “The presence of joint symptoms during steroid tapering is a significant risk factor for the development of pouchitis in patients who have undergone an ileal pouch-anal anastomosis forulcerative colitis.”