Iirritable bowel syndrome (IBS) is a heterogeneous disorder affecting 12% of the population worldwide.
Several studies identify irritable bowel syndrome as a sequela of infectious gastroenteritis with reported prevalence ranging from 4% to 31% and relative risk from about 3 to 12.
Dr Heather Halvorson and colleagues from Egypt conducted a meta-analysis to explore the differences between reported rates and provide a pooled estimate of risk for postinfectious IBS.
The team's data were abstracted from included studies by 2 independent investigators.
Study quality, heterogeneity, and publication bias were assessed.
The investigative team performed a sensitivity analysis, and a summative effect estimate was calculated for risk of postinfectious-IBS.
|There is an association between postinfectious-IBS risk and infectious gastroenteritis|
|American Journal of Gastroenterology|
The investigators identified 8 studies for analysis and all reported elevated risk of IBS following infectious gastroenteritis.
Median prevalence of IBS in the infectious gastroenteritis groups was 10% and 1% in control groups.
The team found that the pooled odds ratio was 7 without significant heterogeneity.
Subgroup analysis revealed an association between postinfectious-IBS risk and infectious gastroenteritis definition used.
Dr Halvorson's team concluded, “This study provides supporting evidence for postinfectious-IBS as a sequela of infectious gastroenteritis.”
“A pooled risk estimate revealed a 7-fold increase in the odds of developing IBS following infectious gastroenteritis.”
“The results suggest that the long-term benefit of reduced postinfectious-IBS may be gained from primary prevention of infectious gastroenteritis.”