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 23 November 2017

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News

Infectious gastroenteritis increases the risk of IBS

This month's issue of the American Journal of Gastroenterology reveals a 7-fold increase in the odds of developing IBS following infectious gastroenteritis.

News image

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Iirritable bowel syndrome (IBS) is a heterogeneous disorder affecting 12% of the population worldwide.

Several studies identify irritable bowel syndrome as a sequela of infectious gastroenteritis with reported prevalence ranging from 4% to 31% and relative risk from about 3 to 12.

Dr Heather Halvorson and colleagues from Egypt conducted a meta-analysis to explore the differences between reported rates and provide a pooled estimate of risk for postinfectious IBS.

The team's data were abstracted from included studies by 2 independent investigators.

Study quality, heterogeneity, and publication bias were assessed.

The investigative team performed a sensitivity analysis, and a summative effect estimate was calculated for risk of postinfectious-IBS.

There is an association between postinfectious-IBS risk and infectious gastroenteritis
American Journal of Gastroenterology

The investigators identified 8 studies for analysis and all reported elevated risk of IBS following infectious gastroenteritis.

Median prevalence of IBS in the infectious gastroenteritis groups was 10% and 1% in control groups.

The team found that the pooled odds ratio was 7 without significant heterogeneity.

Subgroup analysis revealed an association between postinfectious-IBS risk and infectious gastroenteritis definition used.

Dr Halvorson's team concluded, “This study provides supporting evidence for postinfectious-IBS as a sequela of infectious gastroenteritis.”

“A pooled risk estimate revealed a 7-fold increase in the odds of developing IBS following infectious gastroenteritis.”

“The results suggest that the long-term benefit of reduced postinfectious-IBS may be gained from primary prevention of infectious gastroenteritis.”

Am J Gastroenterol 2006: 101(8): 1894
17 August 2006

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