Dr Adria Condino and colleagues determined the proportion of acid and nonacid reflux events in 24 children with asthma from 2004 to 2005.
The children, aged 5 months to 6 years, were suspected to have gastroesophageal reflux (GERD).
The researchers used combined impedance-pH monitoring to determine the symptom index for nonacid and acid reflux events.
Exclusion criteria were congenital anomalies, cerebral palsy, mental retardation, and cardiac disease.
The children underwent a 20-hour multichannel intraluminal impedance-pH study.
The research team found that multichannel intraluminal impedance-pH detected 1184 reflux events, versus 419 reflux events by pH alone.
|331 cases of cough were mostly not associated with a reflux event|
|Journal of Pediatrics|
The team noted that 51% of events were nonacid.
The proportion of nonacid reflux events decreased with time elapsed from last meal.
The team recorded a total of 555 symptoms were recorded.
Of these, 331 were cases of cough, of which most were not associated with a reflux event.
The symptom index for multichannel intraluminal impedance-pH was significantly different than that for the pH probe.
Dr Condino's team concludes, “Acid and nonacid reflux occurs with equal frequency in children with asthma.”
“Most symptoms occur in the absence of a reflux event.”