The long-term benefits of antiviral therapies for chronic Hepatitis C are influenced by the frequency of characteristics that affect response in the population treated.
Dr Omana Nainan and colleagues determined Hepatitis C genotypes and RNA titers among Hepatitis C-infected persons in the general population of the United States.
The team determined genotypes from the NS5b region.
The researchers assessed 275 Hepatitis C RNA-positive participants in the Third National Health and Nutrition Examination Survey conducted during 1988 to 1994.
The research team identified that the Hepatitis C genotypes included 1a, 1b, 2a, 2b, 3a, 4, and 6.
|Genotype 1 occurred in 91% of non-Hispanic blacks|
Based on weighted analysis of persons infected with genotypes 1, 2, and 3, genotype 1 predominated in all age groups.
By racial/ethnic group, the team found genotype 1 in 91% of non-Hispanic blacks, 70% of non-Hispanic whites, and 71% of Mexican Americans.
After adjusting for age and gender, only non-Hispanic black race/ethnicity was independently associated with genotype 1 infection.
The researchers observed that the overall geometric mean concentration of Hepatitis C RNA was 2.1 × 106 IU/mL.
Concentrations above 2 million IU/mL were found in 53% overall, and 50% of persons with genotype 1.
Dr Nainan's team commented, “Persons with chronic Hepatitis C in the United States who may require treatment in the foreseeable future are predominantly infected with genotype 1, including a disproportionate number of non-Hispanic blacks.”
“These features emphasize the need for improved therapies that reduce or eliminate complications from genotype 1 infections.”