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 24 November 2017

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News

Hep C genotype 1 predominates in the USA

Persons with Hep C are predominantly infected with genotype 1, including a disproportionate number of non-Hispanic blacks, shows this month's Gastroenterology.

News image

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The long-term benefits of antiviral therapies for chronic Hepatitis C are influenced by the frequency of characteristics that affect response in the population treated.

Dr Omana Nainan and colleagues determined Hepatitis C genotypes and RNA titers among Hepatitis C-infected persons in the general population of the United States.

The team determined genotypes from the NS5b region.

The researchers assessed 275 Hepatitis C RNA-positive participants in the Third National Health and Nutrition Examination Survey conducted during 1988 to 1994.

The research team identified that the Hepatitis C genotypes included 1a, 1b, 2a, 2b, 3a, 4, and 6.

Genotype 1 occurred in 91% of non-Hispanic blacks
Gastroenterology

Based on weighted analysis of persons infected with genotypes 1, 2, and 3, genotype 1 predominated in all age groups.

By racial/ethnic group, the team found genotype 1 in 91% of non-Hispanic blacks, 70% of non-Hispanic whites, and 71% of Mexican Americans.

After adjusting for age and gender, only non-Hispanic black race/ethnicity was independently associated with genotype 1 infection.

The researchers observed that the overall geometric mean concentration of Hepatitis C RNA was 2.1 × 106 IU/mL.

Concentrations above 2 million IU/mL were found in 53% overall, and 50% of persons with genotype 1.

Dr Nainan's team commented, “Persons with chronic Hepatitis C in the United States who may require treatment in the foreseeable future are predominantly infected with genotype 1, including a disproportionate number of non-Hispanic blacks.”

“These features emphasize the need for improved therapies that reduce or eliminate complications from genotype 1 infections.”

Gastroenterol 2006: 131(2): 478-84
14 August 2006

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