Despite declining incidence rates, gastric cancer is a major cause of death worldwide.
Its etiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols.
Dr Jenab and colleagues determined the association of plasma levels of 7 common carotenoids, retinol, and tocopherol with the risk of gastric adenocarcinoma.
The investigative team conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition involving 10 countries.
Analytes were measured by the team using high-performance liquid chromatography in prediagnostic plasma from 244 gastric cancer cases.
The investigators compared the results with 645 controls matched by age, gender, study centre and date of blood donation.
|There was a negative association with the highest quartile of cryptoxanthin|
|British Journal of Cancer|
Conditional logistic regression models were adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status.
The investigators used the adjusted regression models to estimate relative cancer risks.
The team observed a negative association with gastric cancer risk in the highest vs the lowest quartiles of plasma-cryptoxanthin after 3 years.
There was also a negative association with zeaxanthin, retinol, and lipid-unadjusted-tocopherol and gastric cancer.
For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite.
The investigators noted a diffuse histological subtype, and an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted-tocopherol.
Dr Jenab's team concluded, “These results show that higher plasma concentrations of some carotenoids, retinol and -tocopherol are associated with reduced risk of gastric cancer.”