The prevalence and risk factors for diabetes mellitus after liver transplantation are not well understood.
Dr Saaba and colleagues identified independent risk factors for the development of diabetes after liver transplantation.
The researchers studied the prevalence and risk factors in 253 adult recipients transplanted at UCLA between 1998 and 2002.
Analysis of the retrospective data was performed using demographic, immunosuppression and liver disease variables.
Factors found to be significant on a univariate analysis were further studied in a multivariate analysis.
|The prevalence of diabetes after transplantation was 18%|
|American Journal of Transplantation|
The researchers included 158 men and 95 women, with a mean age of 51 years.
The research team noted that the mean pretransplant body mass index was 27.
Most patients were transplanted for Hepatitis C.
The prevalence of diabetes after transplantation was 18%.
Using a multivariate analysis, the researchers observed that only gender was independently predictive of the development of diabetes.
Dr Saaba's team concludes, “This study in a large liver transplant recipient population identifies male gender as an independent risk factor for the development of diabetes.”
“Follow-up studies are needed to assess the impact of diabetes, and its intervention on post-transplant morbidity and mortality.”