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News

Obesity is a risk of mortality in acute pancreatitis

Obesity is a risk factor for local and systemic complications in acute pancreatitis, and increases the mortality of this disease, reports the latest issue of Pancreatology.

News image

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Obesity is considered a risk factor in patients with acute pancreatitis.

However, the relationship between obesity and mortality in this disease has not been confirmed definitively even in a previous meta-analysis.

Dr Martínez and colleagues from Spain have previously conducted a meta-analysis.

Since this publication, 1 more study has been reported about the prognostic value of obesity in acute pancreatitis.

The research team performed a new meta-analysis to confirm the relationship between obesity and the outcome of acute pancreatitis.

The team conducted a MEDLINE search using pancreatitis, obesity and body mass index as search terms.

The team investigated clinical studies measuring the prognostic value of obesity in acute pancreatitis.

The studies assessed mild and severe acute pancreatitis, used body mass index as the measure of obesity.

Obesity was defined as a body mass index of 30 kg/m2.

The studies included a total of 739 patients
Pancreatology

The severity of acute pancreatitis was defined according to the criteria established in the Atlanta Symposium.

The researchers analyzed 5 studies including patients with mild and severe acute pancreatitis and obesity measured by body mass index.

The end points of the meta-analysis were the severity of acute pancreatitis, local complications, systemic complications and mortality.

The team calculated pooled odds ratio and confidence intervals according to the Mantel-Haenszel method.

Heterogeneity was assessed by the multiplicative inverse variance method.

The studies included a total of 739 patients.

The team noted no heterogeneity for the variables severity, systemic complications, local complications and mortality among the included studies.

Severe acute pancreatitis was significantly more frequent in obese patients.

In addition, the team observed that obese patients developed significantly more systemic, and especially local complications.

In this new analysis, mortality was also higher in obese patients.

Dr Martínez's team concluded, “Obesity is not only a risk factor for the development of local and systemic complications in acute pancreatitis.”

“It also increases the mortality of this disease.”

Pancreatology 2006: 6(3): 206-9
25 July 2006

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