Risks of hepatocellular carcinoma following Hepatitis B and/or Hepatitis C virus infection are well known.
Those for other cancers are less well understood.
Dr Janaki Amin and colleagues from Australia quantified the risk of cancers among persons diagnosed with Hepatitis B and C infections.
The team accessed data from 39,109 Hepatitis B, 75,834 Hepatitis C, and 2604 co-infected persons notified to the State health department from 1990 to 2002.
The team of doctors probabilistically linked the data to the Cancer Registry.
Standardized incidence ratios for cancer were calculated.
|The standardized incidence ratio for hepatocellular carcinoma was 32 for Hep B|
|Journal of Hepatology|
The match rate for any cancer was 3%, 2% and 3% for Hepatitis B, Hepatitis C and co-infected notifications, respectively.
The doctors found that the standardized incidence ratios for hepatocellular carcinoma were 32, 23, and 30, for Hepatitis B, C and co-infection, respectively.
The team detected an increased risk for Burkitt's lymphoma and Hepatitis B, and immunoproliferative malignancies following Hepatitis C.
Dr Amin's team concluded, “The risk of hepatocellular carcinoma in the infected cohort was 20 to 30 times greater than in the uninfected population with standardized incidence ratios 2 to 3 times greater than those for the other Hepatitis B/Hepatitis C infection associated cancers.”
The modest though significant risk of immunoproliferative malignancies associated with Hepatitis C infection is consistent with recent findings.”