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 23 February 2018

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News

Doubling of deaths from liver cancer in 30 years

Deaths from liver cancer have almost doubled in the past 30 years, shows research in Gut.

News image

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A relatively rare type of liver cancer arising from the bile ducts - intrahepatic cholangiocarcinoma - accounts for virtually all of the increase.

The research team analyzed deaths, coded by liver tumor, between 1968 and 1998, using national statistics for England and Wales.

The information was assessed against expected death rates for a given age group per 100,000 of the population.

1968-1996 deaths from cholangiocarcinoma 15 times higher in people aged 45+ years.
Gut
Deaths from all types of liver tumor steadily increased over the period, in both men and women, but the sharpest increase was seen in deaths from intrahepatic cholangiocarcinoma.

In 1996, deaths from this tumor were 15 times higher than they were in 1968 in people aged 45 and older, rising from 38 to 736. By 1998, the totals had reached 864, with the sharpest rises seen among women.

Intrahepatic cholangiocarcinoma is now the commonest cause of death from liver cancer in England and Wales, and has been since 1993.

The reasons for the increase are not immediately obvious, say the authors.

Better diagnosis or diagnostic misclassification may be partially responsible, but they suggest that these factors are unlikely to account fully for the figures.

Thorotrast, a now banned substance that was used in radiology, smoking, and alcohol, and an increase in environmental estrogen have all been linked to this type of tumor.

However, an increase in other environmental toxins may also have a role in the development of bile duct tumors, conclude Dr Simon Taylor-Robinson and fellow authors.

Gut 2001; 48: 816-20
18 May 2001

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