Transient elastography is a novel and non-invasive technique for the evaluation of fibrosis in chronic liver disease.
Few studies that exist value the efficacy of transient elastography, mainly in Hepatitis C virus-infected patients.
Dr Gomez-Dominguez and colleagues from Spain evaluated the effectiveness, objectivity, reproducibility and safety of this technique.
The researchers included 103 consecutive patients who underwent a liver biopsy in the last 48 months with a wide spectrum of chronic liver diseases.
The team kept median stiffness value as representative of the liver elastic modulus.
|Median value of moderate fibrosis was 16 kPa|
|Alimentary Pharmacology & Therapeutics|
All biopsy specimens were analyzed by the same pathologist according to the METAVIR scoring system.
Median value of stiffness in patients with mild or moderate fibrosis, and severe fibrosis or cirrhosis was 7 and 16 kPa, respectively.
The researchers found a significant difference between them.
The areas under the receiver operating characteristic curves showed the optimal liver stiffness cut-off values for each group.
Dr Gomez-Dominguez's team concludes, “We found a positive correlation between the liver stiffness found by transient elastography and fibrosis stage on biopsy in all patients, independently of the liver disease etiology.”
“Transient elastography is an easy, quick to perform and safe non-invasive procedure, reliable for assessing liver fibrosis.”