Dr Peter Siersema and colleagues from the Netherlands identified risk factors for esophageal adenocarcinoma in Barrett's esophagus.
The research team performed a hospital-based case-control study.
The team assessed 91 cases with esophageal adenocarcinoma, and 244 controls with histologically confirmed Barrett's.
Patients with no dysplasia or low-grade dysplasia were included.
Information on demographic, anthropometric, lifestyle characteristics, and physical activity levels were collected by questionnaire.
The researchers also evaluated working posture, family history, gastroesophageal reflux disease (GERD) symptoms, and medication use.
| Nonsteroidal anti-inflammatory drug use was more common among cases|
|American Journal of Gastroenterology|
The team found that cases more often were current smokers, more often had a body mass index of 25 or more assessed at age 20.
Cases also more frequently had been working in a stooped posture at age 20, compared to controls.
In addition, the team noted that cases experienced symptoms of heartburn less often, and less frequently used proton pump inhibitors vs controls.
However, use of nonsteroidal anti-inflammatory drugs/aspirin was more common among cases.
The team observed that cases more often were men, compared with controls.
Dr Siersema's team commented, “In patients with Barrett's esophagus, the risk of esophageal adenocarcinoma is related to risk factors for GERD, which is, however, asymptomatic.”
“As these risk factors are common in Western countries, they are probably not helpful in individualization of surveillance intervals.”