Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 23 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Sustained viral response prolongs hepatocellular carcinoma survival

Interferon therapies before and after Hep C-associated hepatocellular carcinoma development prolongs survival when sustained virologic response is achieved, finds July's Liver International.

News image

fiogf49gjkf04

Dr Masatoshi Akamatsu and colleagues from Japan evaluated interferon therapy in treating Hepatitis C virus-associated hepatocellular carcinoma.

The team of doctors compared overall and recurrence-free survival rates between 191 patients who received interferon therapy before hepatocellular carcinoma development.

Of these, 15 had sustained virologic response, and 53 received interferon therapy after hepatocellular carcinoma ablation.

The team noted that 17 of the 53 patients receiving interferon therapy had sustained virologic response.

A further 399 patients included as controls had hepatocellular carcinoma with Child-Pugh class A liver function.

The control patients did not receive interferon.

Sustained virologic response after hepatocellular carcinoma was 100% at 3 years
Liver International

The doctors found overall survival rate in the controls was 82%, 53%, and 28% at 3, 6, and 9 years, respectively.

Those who developed hepatocellular carcinoma after achieving sustained virologic response, the response rate was 93%, 93%, and 93%, respectively over that time.

The survival rate in those with hepatocellular carcinoma after non-sustained virologic response was 88%, 57%, and 36%, respectively.

The team found that sustained virologic response after hepatocellular carcinoma was 100%, 88%, and 60% at 3, 6, and 9 years.

Over the same time period, the non-sustained virologic response after hepatocellular carcinoma was 94%, 71%, and 53%, respectively.

Cox proportional hazard regression analysis revealed that the risk of death was reduced with hepatocellular carcinoma after sustained virologic response.

The doctors found that the risk ratio for hepatocellular carcinoma was 0.12.

The team noted that patients with sustained virologic response after hepatocellular carcinoma had with a risk ratio of 0.39 compared with the controls.

Improved survival was attributable mainly to sustained liver function among patients with sustained virologic response.

The doctors observed that recurrence-free survival did not differ significantly.

Dr Akamatsu's team concluded, “Interferon therapies before and after hepatocellular carcinoma development were both significantly associated with prolonged survival when sustained virologic response was achieved.”

Liver Internat 2006:26(5):536
03 July 2006

Go to top of page Email this page Email this page to a colleague

 23 November 2017 
Pharmacological management of GERD
 23 November 2017 
Incidence of biopsy-verified celiac disease
 23 November 2017 
Distance travelling for rectal cancer outcomes
 22 November 2017 
Challenges of US-trained gastroenterologists when abroad
 22 November 2017 
Surgical treatment delays influence survival in colon cancer
 22 November 2017 
Golimumab in Crohn's disease
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 21 November 2017 
Prepregnancy obesity and maternal mortality
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 15 November 2017 
Medication nonadherence and health care costs
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Autoimmune pancreatitis in children
 01 November 2017 
Heartburn relief in adolescents with GERD
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's
 26 October 2017 
Conversion to open laparotomy in rectal cancer
 25 October 2017 
Conversion of colonoscopy to sigmoidoscopy
 25 October 2017 
Fecal microbiota transplantation

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us