Some, but not all studies have shown that the CagA status of Helicobacter pylori strains is a predictive factor for the outcome of eradication therapy.
Dr Suzuki and colleagues from Japan determined the association between CagA status and eradication outcome.
The team systematically reviewed studies reporting the successful and failed cases in H pylori-eradication therapy according to the CagA status.
The research team identified 325 articles, of which 14 studies with 1529 patients met the inclusion criteria.
|The summary risk ratio for eradication failure with a CagA-negative status was 2|
|Alimentary Pharmacology & Therapeutics|
The pooled risk ratio for H pylori-eradication failure in CagA-negative relative to CagA-positive strains was used as summary statistics.
The team also used the pooled risk difference in eradication success between the 2 groups as summary statistics.
Meta-regression was used for examining the source of heterogeneity.
The researchers found that the summary risk ratio for eradication failure in CagA-negative relative to CagA-positive was 2.
The team noted that this corresponded with the summary risk difference for eradication success between the groups of 11%.
Meta-regression analysis demonstrated that usage of polymerase chain reaction examination for CagA status was a factor for heterogeneity among studies.
A further factor for heterogeneity was the high proportion of non-ulcer dyspepsia patients among studies.
Dr Suzuki's team concluded, “The meta-analysis confirmed the importance of the presence of CagA as a predictor for successful eradication of H pylori."