There is increasing evidence that a systemic inflammatory response plays a role in survival following curative resection for colorectal cancer.
Dr Crozier and colleagues from England evaluated the relationship between C-reactive protein and survival in colorectal cancer.
The researchers assessed 222 patients receiving adjuvant 5-fluorouracil chemotherapy following curative resection for colorectal cancer.
Of these, 50 patients received adjuvant 5-fluorouracil -based chemotherapy.
The research team measured circulating concentrations of C-reactive protein prior to surgery.
|Elevated C-reactive protein was associated with survival|
|British Journal of Cancer|
The minimum follow-up was 15 months.
The team reported that the median follow-up of the survivors was 38 months.
During this period 61 patients died, 32 patients of their cancer and 29 of intercurrent disease.
The researchers found that age, dukes stage, and an elevated C-reactive protein were significantly associated with survival.
In those patients who did receive adjuvant chemotherapy, an elevated C-reactive protein concentration was significantly associated with survival.
Dr Crozier's team concluded, “The presence of a systemic inflammatory response is an independent predictor of poor outcome in patients receiving adjuvant 5-fluorouracil -based chemotherapy following potentially curative resection for colorectal cancer.”