Individuals with a family history or with Peutz-Jeghers syndrome have an increased risk for pancreatic cancer.
In this study, researchers screened for early pancreatic neoplasia, and compared pancreatic abnormalities in high-risk individuals and controls.
The study included 78 high-risk patients and 149 controls.
High-risk individuals were evaluated using baseline and 12-month computed tomography (CT) scan and endoscopic ultrasonography (EUS).
If the team found EUS to be abnormal, EUS-fine-needle aspiration and endoscopic retrograde cholangiopancreatography (ERCP) were performed.
Overall, 8 patients had pancreatic neoplasia confirmed by surgery or fine-needle aspiration.
Of these, 6 patients had 8 benign intraductal papillary mucinous neoplasms (IPMNs), 1 had an IPMN that progressed to invasive ductal adenocarcinoma, and 1 had pancreatic intraepithelial neoplasia.
EUS and CT also diagnosed 3 patients with 5 extrapancreatic neoplasms.
The team found that abnormalities suggestive of chronic pancreatitis were more common in high-risk patients than in control subjects.
Dr Marcia Irene Canto's team concluded, "Screening EUS and CT diagnosed significant asymptomatic pancreatic and extrapancreatic neoplasms in high-risk individuals".
"IPMN should be considered a part of the phenotype of familial pancreatic cancer".
"Abnormalities suggestive of chronic pancreatitis are identified more commonly at EUS and ERCP in high-risk individuals".