Patients with ulcerative colitis are at increased risk of colorectal cancer.
Little is known about how ulcerative colitis impacts colorectal cancer prognosis.
Dr Sørensen from Massachusetts conducted a nationwide population-based study.
The researchers examined the colorectal cancer prognosis in ulcerative colitis patients compared to colorectal cancer patients without ulcerative colitis.
The research team accessed the Danish Cancer Registry and the Danish Hospital Discharge Registry.
The team identified all colorectal cancer patients and all patients with ulcerative colitis in Denmark from 1977 to 1999.
The survival in 279 ulcerative colitis patients with colorectal cancer was compared to all other 71,259 colorectal cancer patients.
Computed mortality rate ratios were calculated.
The researchers compared stage distribution at time of cancer diagnosis.
|The cancer stage distribution for localized cancer in patients without ulcerative colitis was 44%|
|American Journal of Gastroenterology|
The mean age at time of colorectal cancer diagnosis was 63 years in ulcerative colitis patients.
The team noted that the mean age was 71 years in patients without ulcerative colitis.
Cancer stage distribution for localized cancer, regional spread, and distant metastasis were 47%, 30%, and 17% in ulcerative colitis patients.
The researchers found that in patients without ulcerative colitis, the cancer stage distribution for localized cancer, regional spread, and distant metastasis was 44%, 28%, and 19%, respectively.
The overall mortality ratio rate for ulcerative colitis patients with colorectal cancer was 1.2 in the first year and 1.17 after 5 year of follow-up.
Dr Sørensen's team concluded, “Ulcerative colitis patients with colorectal cancer have a stage distribution similar to patients with colorectal cancer without ulcerative colitis.”
“The prognosis of colorectal cancer is poorer for ulcerative colitis patients than for patients without ulcerative colitis.”